Week 3 NFL picks, odds, 2022 best bets from advanced model: This 5-way football parlay pays out 25-1

The Arizona Cardinals will try to avenge last year’s playoff loss when they host the defending Super Bowl champion Los Angeles Rams during the Week 3 NFL schedule. Arizona, which was one of three teams to post a victory last week after trailing by at least 13 points in the fourth quarter, was trounced 34-11 at Los Angeles in the wild-card round of the 2021 postseason. The Rams are 3.5-point favorites in the latest Week 3 NFL odds at Caesars Sportsbook. Other Week 3 NFL spreads include Buffalo as a 5.5-point favorite against Miami and Green Bay as a 2-point underdog versus Tampa Bay. Which Week 3 NFL lines should you target with your Week 3 NFL bets? Before you make any Week 3 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2022 NFL season on an incredible 139-102 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 3. If you successfully parlay its picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Week 3 NFL picks at SportsLine.

Top Week 3 NFL picks

After simulating every game 10,000 times, the model is high on the Cincinnati Bengals (-6) to win and cover against the New York Jets on Sunday. Joe Burrow will be eager to avoid the second season-opening three-game winless streak of his three-year career, as Cincinnati went 0-2-1 before posting its first win of 2020 in Week 4 against Jacksonville. The 2021 NFL Comeback Player of the Year had a solid showing in last season’s 34-31 loss at New York, completing 21-of-34 pass attempts for 259 yards and three touchdowns.

The Jets did not record back-to-back victories in 2021, following each of their four wins with at least two consecutive defeats. Cincinnati is ready to make that trend continue and record its first victory of the season, and the model has the Bengals covering the spread almost 60% of the time. See which other NFL parlay picks to make here.

How to make Week 3 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including backing a shocking team even though they were dominated last week. You can only see the model’s NFL Week 3 best bets and parlay at SportsLine.

What are the model’s top Week 3 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 3 NFL best bets from a model on a 139-102 run on its top-rated picks, and find out.

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